Peptide–LNA oligonucleotide conjugates
نویسندگان
چکیده
منابع مشابه
Peptide-LNA oligonucleotide conjugates.
Although peptide-oligonucleotide conjugates (POCs) are well-known for nucleic acids delivery and therapy, reports on internal attachment of peptides to oligonucleotides are limited in number. To develop a convenient route for preparation of internally labeled POCs with improved biomedical properties, peptides were introduced into oligonucleotides via a 2'-alkyne-2'-amino-LNA scaffold. Derivativ...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2013
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c3ob40786a